反应详情

The mixture of pyrazoles of examples 13C and 13D (2.35 g, 6.772 mmol) was taken up in dry THF (100 ml) and degassed. 5% Pd.-on-carbon (1.2 g) was added and the mixture hydrogenated at 30 psi and ambient temperature for 2 h. The mixture was filtered (celite filter aid) and evaporated and then chromatographed (eluant 30% EtOAc in hexanes) to provide the two tide compounds as an equimolar mixture (1.05 g, 49%).

1. customdegassed
2. addition-on-carbon (1.2 g) was added
3. filtrationThe mixture was filtered
4. filtration(celite filter aid)
5. customevaporated
6. customchromatographed (eluant 30% EtOAc in hexanes)