反应详情

To a solution of 2-(3-methoxyphenyl)pyrrolidine (3.0 g) in dry acetonitrile (70 ml) was added milled potassium carbonate (6.1 g) followed by 3-picolyl chloride hydrochloride (3.1 g) at ambient temperature, under nitrogen, with stirring. The reaction mixture was stirred for 65 hrs, filtered through a pad of celite, and the filter cake was washed with ethyl acetate. The combined filtrates were concentrated, and the residue was purified by flash column chromatography (silica gel, 5% methanol/ether). The appropriate fractions were collected and concentrated to give 3.7 g (83%) of 2-(3-methoxyphenyl)-1-(3-pyridinylmethyl)pyrrolidine.

1. stirringThe reaction mixture was stirred for 65 hrs
2. filtrationfiltered through a pad of celite
3. washthe filter cake was washed with ethyl acetate
4. concentrationThe combined filtrates were concentrated
5. customthe residue was purified by flash column chromatography (silica gel, 5% methanol/ether)
6. customThe appropriate fractions were collected
7. concentrationconcentrated