Hydrochloric Acid → 4-Chloro-6-[4-(2-trifluoromethyl-phenyl)-piperidin-1-yl]-pyrimidin-2-ylamine
Reaction equation
[C:27](=[O:28])([O-:29])[O-:30].[CH2:33]1[O:34][CH2:35][CH2:36][O:37][CH2:38]1.[ClH:10].[Cs+:31].[Cs+:32].[F:11][C:12]([c:13]1[c:14]([CH:19]2[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]2)[cH:15][cH:16][cH:17][cH:18]1)([F:25])[F:26].[NH2:1][c:2]1[n:3][c:4]([Cl:9])[cH:5][c:6]([Cl:8])[n:7]1.[OH2:39]>>[NH2:1][c:2]1[n:3][c:4]([N:22]2[CH2:21][CH2:20][CH:19]([c:14]3[c:13]([C:12]([F:11])([F:25])[F:26])[cH:18][cH:17][cH:16][cH:15]3)[CH2:24][CH2:23]2)[cH:5][c:6]([Cl:8])[n:7]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-34fce5adbc354bbb96a5880677b9a83a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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