反应详情

To a solution of 2-(3-methoxyphenyl)pyrrolidine (1.04 g) in dry acetonitrile (30 ml) was added 2-bromoethylbenzene (0.96 ml) followed by milled potassium carbonate (1.78 g) at ambient temperature, under nitrogen. The reaction mixture was stirred for 48 hrs, warmed under reflux for 2 hrs, and cooled to ambient temperature. The reaction mixture was filtered through a pad of celite, and the filter cake was washed with ethyl acetate. The combined filtrates were concentrated and the residue was purified by flash column chromatography (silica gel, dichloromethane/0-100% ether). The appropriate fractions were collected and concentrated to afford 1.2 g (72%) of 2-(3-methoxyphenyl)-1-(2-phenylethyl)pyrrolidine.

1. temperaturewarmed
2. temperatureunder reflux for 2 hrs
3. filtrationThe reaction mixture was filtered through a pad of celite
4. washthe filter cake was washed with ethyl acetate
5. concentrationThe combined filtrates were concentrated
6. customthe residue was purified by flash column chromatography (silica gel, dichloromethane/0-100% ether)
7. customThe appropriate fractions were collected
8. concentrationconcentrated