Hydrogen Bromide → N-[4'-(2-Amino-4-thiazolyl)-6-methyl-[1,1'-biphenyl]-3-yl]-2-(1-pyrrolidinyl)-4-pyridinecarboxamide

HRID 2330595Notes

Reaction equation

HRID 2330595 reaction equation
[Br:2][c:3]1[cH:4][cH:5][c:6](-[c:9]2[n:10][c:11]([NH2:14])[s:12][cH:13]2)[cH:7][cH:8]1.[BrH:1].[CH3:15][c:16]1[c:17]([B:36]2[O:37][C:38]([CH3:39])([CH3:40])[C:41]([CH3:42])([CH3:43])[O:44]2)[cH:18][c:19]([NH:22][C:23](=[O:24])[c:25]2[cH:26][c:27]([N:31]3[CH2:32][CH2:33][CH2:34][CH2:35]3)[n:28][cH:29][cH:30]2)[cH:20][cH:21]1>>[c:3]1(-[c:17]2[c:16]([CH3:15])[cH:21][cH:20][c:19]([NH:22][C:23](=[O:24])[c:25]3[cH:26][c:27]([N:31]4[CH2:32][CH2:33][CH2:34][CH2:35]4)[n:28][cH:29][cH:30]3)[cH:18]2)[cH:4][cH:5][c:6](-[c:9]2[n:10][c:11]([NH2:14])[s:12][cH:13]2)[cH:7][cH:8]1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 6206834-(4-Bromophenyl)-1,3-thiazol-2-amineHCID 11258289N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-2-pyrrolidin-1-yl-isonicotinamide

Product 1

HCID 10072721N-[4'-(2-Amino-4-thiazolyl)-6-methyl-[1,1'-biphenyl]-3-yl]-2-(1-pyrrolidinyl)-4-pyridinecarboxamide

Sources & evidence

ORD record
ord-e5df57c45e2f43d4840c24d8c1c76b99
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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