Dichloromethane → 1-(methoxy-methyl-carbamoyl)-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester

HRID 2330752Notes

Reaction equation

HRID 2330752 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[n:11]([c:14]([C:20]([F:21])([F:22])[F:23])[n:15][c:16]2[C:17](=[O:18])[OH:19])[CH2:12][CH2:13]1.[CH3:24][O:25][NH:26][CH3:27].[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[Cl:50][CH2:51][Cl:52].[O:35]=[C:36]1[N:37]([P:38]([Cl:39])([N:40]2[CH2:41][CH2:42][O:43][C:44]2=[O:45])=[O:46])[CH2:47][CH2:48][O:49]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[n:11]([c:14]([C:20]([F:21])([F:22])[F:23])[n:15][c:16]2[C:17](=[O:19])[N:26]([O:25][CH3:24])[CH3:27])[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 14232N,O-DimethylhydroxylamineHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 575184537-[(tert-Butoxy)carbonyl]-3-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,5-a]pyrazine-1-carboxylic acid

Product 1

HCID 575184541-(methoxy-methyl-carbamoyl)-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-783cc7a0d5b5459d98f61299b10c9ffb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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