Hydroxide → 1-[cis-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-3-(2,6-dichloro-4-hydroxy-benzyl)-pyrrolidin-2-one

HRID 2330898Notes

Reaction equation

HRID 2330898 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]([Cl:37])[c:12]([CH2:13][CH:14]2[C:15](=[O:33])[N:16]([CH:19]3[CH2:20][CH2:21][CH:22]([O:25][Si:26]([CH3:27])([CH3:28])[C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:23][CH2:24]3)[CH2:17][CH2:18]2)[c:34]([Cl:36])[cH:35]1.[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[OH-:38].[OH-:39].[Pd+2:40]>>[OH:8][c:9]1[cH:10][c:11]([Cl:37])[c:12]([CH2:13][CH:14]2[C:15](=[O:33])[N:16]([CH:19]3[CH2:20][CH2:21][CH:22]([O:25][Si:26]([CH3:27])([CH3:28])[C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:23][CH2:24]3)[CH2:17][CH2:18]2)[c:34]([Cl:36])[cH:35]1

Participants

5

Reactant 4

HCID 961Hydroxide2×HCID 8028TetrahydrofuranHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 592994163-(4-Benzyloxy-2,6-dichloro-benzyl)-1-[cis-4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-pyrrolidin-2-one

Product 1

HCID 592994681-[cis-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-3-(2,6-dichloro-4-hydroxy-benzyl)-pyrrolidin-2-one

Sources & evidence

ORD record
ord-e613991bd3da4d9aaeac3f60be538ffa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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