Tetrahydrofuran → 4-(4-Hydroxypiperidin-1-yl)benzonitrile

HRID 2330920Notes

Reaction equation

[C:19]([Si:20]([CH3:21])([CH3:22])[O:24][CH:25]1[CH2:26][CH2:27][N:28]([c:31]2[cH:32][cH:33][c:34]([C:35]#[N:36])[cH:37][cH:38]2)[CH2:29][CH2:30]1)([CH3:23])([CH3:39])[CH3:40].[CH2:2]([N+:3]([CH2:4][CH2:5][CH2:6][CH3:7])([CH2:8][CH2:9][CH2:10][CH3:11])[CH2:12][CH2:13][CH2:14][CH3:15])[CH2:16][CH2:17][CH3:18].[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[F-:1]>>[OH:24][CH:25]1[CH2:26][CH2:27][N:28]([c:31]2[cH:32][cH:33][c:34]([C:35]#[N:36])[cH:37][cH:38]2)[CH2:29][CH2:30]1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 16028Tetrabutylammonium

HCID 28179Fluoride Ion

HCID 694805284-[4-(Tert-butyldimethylsiloxy)piperidin-1-yl]benzonitrile

Product 1

HCID 111064164-(4-Hydroxypiperidin-1-yl)benzonitrile

Sources & evidence

ORD record: ord-e7925a211df44d2090110c7a0ef04c42
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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