Potassium Cation → Tert-butyl 4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazine-1-carboxylate

HRID 2330937Notes

Reaction equation

HRID 2330937 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([CH3:21])[cH:18][c:19]2[Cl:20])[CH2:12][CH2:13]1.[CH3:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1.[CH:30]1([B:33]([OH:34])[OH:35])[CH2:31][CH2:32]1.[K+:27].[K+:28].[K+:29].[OH2:43].[P:22]([O-:23])([O-:24])([O-:25])=[O:26]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([CH3:21])[cH:18][c:19]2[CH:30]2[CH2:31][CH2:32]2)[CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 813Potassium Cation3×HCID 962WaterHCID 1061PhosphateHCID 1140TolueneHCID 2760897Cyclopropylboronic acidHCID 673809194-(3-Chloro-5-methylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 49871665Tert-butyl 4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-91b4899cdde14e3e96b929dce6657a1c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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