Dichloromethane → Ethyl 1-[6-(2-{[4-(1,4-dioxaspiro[4.5]dec-8-yl)benzyl]oxy}phenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
Reaction equation
[Cl:79][CH2:80][Cl:81].[O:28]1[CH2:29][CH2:30][O:31][C:32]12[CH2:33][CH2:34][CH:35]([c:38]1[cH:39][cH:40][c:41]([CH2:44][OH:45])[cH:42][cH:43]1)[CH2:36][CH2:37]2.[O:65]=[C:66]([O:67][CH:68]([CH3:69])[CH3:70])[N:71]=[N:72][C:73]([O:74][CH:75]([CH3:76])[CH3:77])=[O:78].[OH:1][c:2]1[c:3](-[c:8]2[cH:9][cH:10][cH:11][c:12](-[n:14]3[n:15][cH:16][c:17]([C:23](=[O:24])[O:25][CH2:26][CH3:27])[c:18]3[C:19]([F:20])([F:21])[F:22])[n:13]2)[cH:4][cH:5][cH:6][cH:7]1.[c:46]1([P:47]([c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[cH:60][cH:61][cH:62][cH:63][cH:64]1>>[O:1]([c:2]1[c:3](-[c:8]2[cH:9][cH:10][cH:11][c:12](-[n:14]3[n:15][cH:16][c:17]([C:23](=[O:24])[O:25][CH2:26][CH3:27])[c:18]3[C:19]([F:20])([F:21])[F:22])[n:13]2)[cH:4][cH:5][cH:6][cH:7]1)[CH2:44][c:41]1[cH:40][cH:39][c:38]([CH:35]2[CH2:34][CH2:33][C:32]3([O:28][CH2:29][CH2:30][O:31]3)[CH2:37][CH2:36]2)[cH:43][cH:42]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-10f663b52ec047c9beec400fd2a70574
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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