HCID 9887252, compound → HCID 23361334, compound

HRID 233114Notes

Reaction equation

HRID 233114 reaction equation
CC1(C)C2C=C(C#CC3C=CC(C(O)=O)=CC=3)C=CC=2C(=O)CC1.[CH3:25][C:26]1([CH3:54])[C:35]2[CH:34]=[C:33]([C:36]#[C:37][C:38]3[CH:48]=[CH:47][C:41]([C:42]([O:44]CC)=[O:43])=[CH:40][CH:39]=3)[CH:32]=[CH:31][C:30]=2[C:29](=[C:49]([CH2:52][CH3:53])[CH2:50][CH3:51])[CH2:28][CH2:27]1>>[CH3:54][C:26]1([CH3:25])[C:35]2[CH:34]=[C:33]([C:36]#[C:37][C:38]3[CH:39]=[CH:40][C:41]([C:42]([OH:44])=[O:43])=[CH:47][CH:48]=3)[CH:32]=[CH:31][C:30]=2[C:29](=[C:49]([CH2:50][CH3:51])[CH2:52][CH3:53])[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 9887252HCID 9887252, compound2×HCID 153455474-((5,6,7,8-Tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]benzoic acid2×

Product 1

HCID 23361334HCID 23361334, compound

Procedure

Employing the same general procedure as for the preparation of 4-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]benzoic acid (Compound 7), 90 mg (0.23 mmol) of ethyl 4-[(7,8-dihydro-8,8-dimethyl-5(6H)-(3-pentylidene)naphth-2-yl)ethynyl]benzoate (Compound 133) was converted to the title compound using 0.5 ml (0.5 mmol) of LiOH (1M aqueuos solution).

Sources & evidence

ORD record
ord-d34cba50ddc443949007dec95b93bacc
Source dataset
uspto-grants-1997_01
Patent number
US05591858

Reaction notes

Loading…