Dichloromethane → 5-Benzyloxy-2-[2-(1,2,3,4-tetrahydro-isoquinolin-7-yl)-ethyl]-2H-pyridazin-3-one

HRID 2331393Notes

Reaction equation

HRID 2331393 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][c:10]2[cH:11][c:12]([CH2:18][CH2:19][n:20]3[n:21][cH:22][c:23]([O:27][CH2:28][c:29]4[cH:30][cH:31][cH:32][cH:33][cH:34]4)[cH:24][c:25]3=[O:26])[cH:13][cH:14][c:15]2[CH2:16][CH2:17]1)([CH3:5])([CH3:6])[CH3:7].[Cl:42][CH2:43][Cl:44].[OH:35][C:36]([C:37]([F:38])([F:39])[F:40])=[O:41]>>[NH:8]1[CH2:9][c:10]2[cH:11][c:12]([CH2:18][CH2:19][n:20]3[n:21][cH:22][c:23]([O:27][CH2:28][c:29]4[cH:30][cH:31][cH:32][cH:33][cH:34]4)[cH:24][c:25]3=[O:26])[cH:13][cH:14][c:15]2[CH2:16][CH2:17]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 670069227-[2-(4-Benzyloxy-6-oxo-6H-pyridazin-1-yl)-ethyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic Acid Tert-Butyl Ester

Product 1

HCID 580427515-Benzyloxy-2-[2-(1,2,3,4-tetrahydro-isoquinolin-7-yl)-ethyl]-2H-pyridazin-3-one

Sources & evidence

ORD record
ord-4fd9007f1499477e858d6b66f5fe1721
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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