Acetic Acid → Tert-butyl 4-cyclobutylpiperazine-1-carboxylate

HRID 2331443Notes

Reaction equation

HRID 2331443 reaction equation
[C:15]1(=[O:19])[CH2:16][CH2:17][CH2:18]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1.[C:20]([BH3-:21])#[N:22].[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[CH3:29][C:30](=[O:31])[OH:32].[Na+:23].[OH2:14]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH:15]2[CH2:16][CH2:17][CH2:18]2)[CH2:12][CH2:13]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 923Sodium ionHCID 962WaterHCID 8028TetrahydrofuranHCID 14496CyclobutanoneHCID 143452tert-Butyl piperazine-1-carboxylateHCID 498716Cyano-borohydride

Product 1

HCID 57423951Tert-butyl 4-cyclobutylpiperazine-1-carboxylate

Sources & evidence

ORD record
ord-e0dd4bb485e54518b578554713abf3f2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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