Trifluoroacetic acid → 2-(1-Ethyl-5-trifluoromethyl-1H-indazol-3-ylamino)-N-{1-[4-hydroxy-4-(2-methyl-thiazol-5-yl)-cyclohexyl]-azetidin-3-yl}-acetamide
Reaction equation
[F:25][C:26]([F:27])([F:28])[C:29]([OH:30])=[O:31].[NH:1]1[CH2:2][CH:3]([NH:5][C:6]([CH2:7][NH:8][c:9]2[n:10][n:11]([CH2:22][CH3:23])[c:12]3[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][c:17]23)=[O:24])[CH2:4]1.[OH:32][C:33]1([c:40]2[cH:41][n:42][c:43]([CH3:45])[s:44]2)[CH2:34][CH2:35][C:36](=[O:39])[CH2:37][CH2:38]1>>[N:1]1([CH:36]2[CH2:35][CH2:34][C:33]([OH:32])([c:40]3[cH:41][n:42][c:43]([CH3:45])[s:44]3)[CH2:38][CH2:37]2)[CH2:2][CH:3]([NH:5][C:6]([CH2:7][NH:8][c:9]2[n:10][n:11]([CH2:22][CH3:23])[c:12]3[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][c:17]23)=[O:24])[CH2:4]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-84a849c596d6488da613c2e715620c79
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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