Dichloromethane → 1-[2-(4-Aminopiperidin-1-yl)ethyl]-6,7-difluoroquinoxalin-2(1H)-one

HRID 2332507Notes

Reaction equation

HRID 2332507 reaction equation
[C:1]([N:5]([C:2](=[O:3])[O-:4])[CH:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][n:17]2[c:18](=[O:29])[cH:19][n:20][c:21]3[cH:22][c:23]([F:28])[c:24]([F:27])[cH:25][c:26]23)[CH2:13][CH2:14]1)([CH3:6])([CH3:7])[CH3:8].[Cl:58][CH2:59][Cl:60].[NH2:37][CH:38]1[CH2:39][CH2:40][N:41]([CH2:42][CH2:43][n:44]2[c:45]3[c:46]([cH:47][cH:48][c:49]([F:50])[cH:51]3)[n:52][cH:53][c:54]2=[O:55])[CH2:56][CH2:57]1.[OH:30][C:31]([C:32]([F:33])([F:34])[F:35])=[O:36]>>[NH2:5][CH:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][n:17]2[c:18](=[O:29])[cH:19][n:20][c:21]3[cH:22][c:23]([F:28])[c:24]([F:27])[cH:25][c:26]23)[CH2:13][CH2:14]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 593979071-(2-(4-aminopiperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-oneHCID 178449657N-tert-butyl-N-[1-[2-(6,7-difluoro-2-oxoquinoxalin-1-yl)ethyl]piperidin-4-yl]carbamate

Product 1

HCID 667743341-[2-(4-Aminopiperidin-1-yl)ethyl]-6,7-difluoroquinoxalin-2(1H)-one

Sources & evidence

ORD record
ord-a495c347954141d78d66d9f1baaf8a1e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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