Tetrahydrofuran → Tert-butyl 3-(2,3-difluoro-6-methyl-4-trimethylsilylbenzoyl)piperidine-1-carboxylate
Reaction equation
[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH3:14][CH2:15][CH2:16][CH2:17][Li:18].[CH3:19][O:20][N:21]([C:22](=[O:23])[CH:24]1[CH2:25][N:26]([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:27][CH2:28][CH2:29]1)[CH3:37].[CH3:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48].[F:1][c:2]1[c:3]([Si:10]([CH3:11])([CH3:12])[CH3:13])[cH:4][c:5]([CH3:9])[cH:6][c:7]1[F:8]>>[F:1][c:2]1[c:3]([Si:10]([CH3:11])([CH3:12])[CH3:13])[cH:4][c:5]([CH3:9])[c:6]([C:22](=[O:23])[CH:24]2[CH2:25][N:26]([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:27][CH2:28][CH2:29]2)[c:7]1[F:8]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-2646bdb37b0f4789957fe3fbf302ef36
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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