Phosphorus tribromide → HCID 23361375, compound

HRID 233293Notes

Reaction equation

HRID 233293 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]O)=[CH:17][CH:16]=1.P(Br)(Br)[Br:28]>>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][Br:28])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 24614Phosphorus tribromideHCID 23361347HCID 23361347, compound

Product 1

HCID 23361375HCID 23361375, compound

Procedure

According to the method described for Reference Example 25, 5-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]-1-pentanol was allowed to react with phosphorus tribromide to give 5-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]pentyl bromide. Recrystallization from ether-hexane gave colorless needles, m.p.58°-59° C.

Sources & evidence

ORD record
ord-96ecebd4cefb4b9f870e67a2f7d6d2d5
Source dataset
uspto-grants-1997_01
Patent number
US05591862

Reaction notes

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