Trimethyl phosphonoacetate → HCID 86754595, compound

HRID 233295Notes

Reaction equation

[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21](=O)[CH3:22])=[CH:17][CH:16]=1.[CH3:24][O:25][C:26]([CH2:28]P(OC)(OC)=O)=[O:27]>>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[N:4][C:3]=1[CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18](/[C:21](/[CH3:22])=[CH:28]/[C:26]([O:25][CH3:24])=[O:27])=[CH:19][CH:20]=1

Participants

Reactant 2

HCID 80029Trimethyl phosphonoacetate

HCID 10638429HCID 10638429, compound

Product 1

HCID 86754595HCID 86754595, compound

Procedure

According to the method described for Reference Example 22, 4'-(5-methyl-2-phenyl-4-oxazolylmethoxy)acetophenone was allowed to react with trimethyl phosphonoacetate gave methyl (E)-3-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]-2-butenoate. Recrystallization from ethyl acetate--hexane gave colorless prisms, m.p.125°-126° C.

Sources & evidence

ORD record: ord-9469f0de31264fdaa1c97f930222d415
Source dataset: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05591862

Reaction notes

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