4-Hydroxybenzaldehyde → HCID 23361359, compound

HRID 233302Notes

Reaction equation

HRID 233302 reaction equation
Cl[CH2:2][C:3]1[S:4][C:5]([CH3:14])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.[OH:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=1>>[CH3:14][C:5]1[S:4][C:3]([CH2:2][O:15][C:16]2[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=2)=[N:7][C:6]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 1264-HydroxybenzaldehydeHCID 199656082-(Chloromethyl)-5-methyl-4-phenylthiazole

Product 1

HCID 23361359HCID 23361359, compound

Procedure

According to the method described for Reference Example 45, 2-chloromethyl-5-methyl-4-phenylthiazole was allowed to react with p-hydroxybenzaldehyde to give 4-(5-methyl-4-phenyl-2-thiazolylmethoxy)benzaldehyde. Recrystallization from ethyl acetate--isopropyl ether gave colorless prisms, m.p.81°-82° C.

Sources & evidence

ORD record
ord-107bf2db2f054d00abf4587183cd8766
Source dataset
uspto-grants-1997_01
Patent number
US05591862

Reaction notes

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