Potassium Cyanide → HCID 23361345, compound

HRID 233320Notes

Reaction equation

HRID 233320 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]2[N:20]=[C:21]([C:25]3[CH:34]=[CH:33][C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH:26]=3)[O:22][C:23]=2[CH3:24])=[CH:13][CH:12]=1)(=O)=O.[C-:35]#[N:36].[K+]>>[CH3:24][C:23]1[O:22][C:21]([C:25]2[CH:34]=[CH:33][C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH:26]=2)=[N:20][C:19]=1[CH2:18][O:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][C:35]#[N:36])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 9032Potassium CyanideHCID 23361371HCID 23361371, compound

Product 1

HCID 23361345HCID 23361345, compound

Procedure

According to the method described for Reference Example 38, 5-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]phenyl]pentyl methanesulfonate was allowed to react with potassium cyanide to give 6-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]phenyl]hexanenitrile. Recrystallization from ethyl acetate--isopropyl ether gave colorless prisms, m.p.116°-117° C.

Sources & evidence

ORD record
ord-d16b9b3b8b0a431b82dd8e2d09888d97
Source dataset
uspto-grants-1997_01
Patent number
US05591862

Reaction notes

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