Diethyl (cyanomethyl)phosphonate → HCID 54037696, compound

HRID 233321Notes

Reaction equation

HRID 233321 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][CH2:14][CH2:15][O:16][C:17]1[CH:24]=[CH:23][C:20]([CH:21]=O)=[CH:19][CH:18]=1.[C:25]([CH2:27]P(=O)(OCC)OCC)#[N:26]>>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][CH2:14][CH2:15][O:16][C:17]1[CH:24]=[CH:23][C:20]([CH:21]=[CH:27][C:25]#[N:26])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 75676Diethyl (cyanomethyl)phosphonateHCID 23361370HCID 23361370, compound

Product 1

HCID 54037696HCID 54037696, compound

Procedure

According to the method described for Reference Example 35, 4-[3-(5-methyl-2-phenyl-4-oxazolyl)propoxy]benzaldehyde was allowed to react with diethyl cyanomethylphosphonate to give 4-[3-(5-methyl-2-phenyl-4-oxazolyl)propoxy]cinnamonitrile. Recrystallization from ethyl acetate--isopropyl ether--hexane gave colorless prisms, m.p.97°-98° C.

Sources & evidence

ORD record
ord-6ecbf345ac714cee9f324d66c4de0acc
Source dataset
uspto-grants-1997_01
Patent number
US05591862

Reaction notes

Loading…