Dimethyl Sulfoxide → (+/-)-3-[3-(2-fluoro-4-methoxy-phenyl)-4-methyl-2-oxo-7-phenylamino-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-1-yl]-benzamide
Reaction equation
[CH3:42][S:43](=[O:44])[CH3:45].[F:1][c:2]1[c:3]([N:10]2[C:11](=[O:36])[N:12]([c:28]3[cH:29][c:30]([C:31]#[N:32])[cH:33][cH:34][cH:35]3)[c:13]3[n:14][c:15]([NH:21][c:22]4[cH:23][cH:24][cH:25][cH:26][cH:27]4)[n:16][cH:17][c:18]3[CH:19]2[CH3:20])[cH:4][cH:5][c:6]([O:8][CH3:9])[cH:7]1.[Na+:38].[OH-:37].[OH2:41].[OH:39][OH:40]>>[F:1][c:2]1[c:3]([N:10]2[C:11](=[O:36])[N:12]([c:28]3[cH:29][c:30]([C:31]([NH2:32])=[O:37])[cH:33][cH:34][cH:35]3)[c:13]3[n:14][c:15]([NH:21][c:22]4[cH:23][cH:24][cH:25][cH:26][cH:27]4)[n:16][cH:17][c:18]3[CH:19]2[CH3:20])[cH:4][cH:5][c:6]([O:8][CH3:9])[cH:7]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-2e7763f8ad5346b2ad8905bbfa2adce6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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