Sodium ion → 4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 2334392Notes

Reaction equation

HRID 2334392 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[nH:15][cH:16][c:17](-[c:19]3[cH:20][c:21]([C:26]([F:27])([F:28])[F:29])[c:22]([F:25])[cH:23][cH:24]3)[n:18]2)[CH2:12][CH2:13]1.[CH3:32][I:33].[CH3:39][CH2:40][O:41][CH2:42][CH3:43].[H-:30].[Na+:31].[O:34]1[CH2:35][CH2:38][CH2:37][CH2:36]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[n:15]([CH3:35])[cH:16][c:17](-[c:19]3[cH:20][c:21]([C:26]([F:27])([F:28])[F:29])[c:22]([F:25])[cH:23][cH:24]3)[n:18]2)[CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 3283Diethyl EtherHCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 166653HydrideHCID 178451792HCID 178451792, compound

Product 1

HCID 666499314-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-f7c6f249444b404b91282bb7a3781527
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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