3-Fluorobenzaldehyde → HCID 54065590, compound

HRID 233448Notes

Reaction equation

HRID 233448 reaction equation
[OH:1][CH:2]([P:9](=[O:16])([O:13][CH2:14][CH3:15])[O:10][CH2:11][CH3:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:17]C1C=C(C=CC=1)C=O>>[F:17][C:5]1[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=1)[CH:2]([P:9](=[O:16])([O:10][CH2:11][CH3:12])[O:13][CH2:14][CH3:15])[OH:1]

Participants

3

Reactant 2

HCID 680093-FluorobenzaldehydeHCID 238674diethoxyphosphoryl-phenyl-methanol

Product 1

HCID 54065590HCID 54065590, compoundYield 79%

Procedure

The procedure described for the preparation of Compound 19 is used except that 3-fluorobenzaldehyde (1.49 g, 0.012M) is used in place of benzaldehyde. The solid obtained is recrystallized from hexane to obtain 2.474 g (0.009 M, 79%) of colorless short needles: mp 81°-82° C.

Workup

  1. customThe solid obtained
  2. customis recrystallized from hexane

Sources & evidence

ORD record
ord-f247d4a486114a768a94fa69919af3f3
Source dataset
uspto-grants-1997_01
Patent number
US05593980

Reaction notes

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