反应详情

A solution of aqueous HF (50%, 12 mL) was added to a mixture of compound 45 (6.3 g, 14.5 mmol) in acetonitrile (120 mL) and the mixture was stirred for 30 min. After completion of the reaction, the acid was neutralized with saturated sodium bicarbonate solution and extracted with ethyl acetate (3×150 mL) and the organic phase was separated, dried, concentrated, and the product was purified by flash chromatography to afford compound 46 as colorless oil (Rf 0.42, 25% ethyl acetate in hexane, 3.4 g, 74%).

1. customAfter completion of the reaction
2. extractionextracted with ethyl acetate (3×150 mL)
3. customthe organic phase was separated
4. customdried
5. concentrationconcentrated
6. customthe product was purified by flash chromatography