Triethylamine → HCID 22911338, compound

HRID 233475Notes

Reaction equation

HRID 233475 reaction equation
C(N(CC)CC)C.[C:8](Cl)(=[O:11])[CH2:9][CH3:10].Cl.[NH2:14][CH:15]1[C:27](=[O:28])[C:26]2[C:18](=[CH:19][C:20]3[CH2:24][CH2:23][O:22][C:21]=3[CH:25]=2)[CH2:17][CH2:16]1>C(Cl)Cl>[O:28]=[C:27]1[C:26]2[C:18](=[CH:19][C:20]3[CH2:24][CH2:23][O:22][C:21]=3[CH:25]=2)[CH2:17][CH2:16][CH:15]1[NH:14][C:8](=[O:11])[CH2:9][CH3:10]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62324Propionyl chlorideHCID 22911339HCID 22911339, compound

Product 1

HCID 22911338HCID 22911338, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

23 ml of triethylamine and 5.7 ml of propionyl chloride are added in succession to 17 g of dl-7-amino- 2,3,6,7-tetrahydro-5H-naphtho[2,3-b]furan-8-one hydrochloride suspended in 170 ml of methylene chloride. After 2 hours' stirring at room temperature, the reaction mixture is washed with water, decanted and concentrated to dryness. 20 g of the desired compound are obtained.

Workup

  1. washthe reaction mixture is washed with water
  2. customdecanted
  3. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-92cde8e4abfa49009a16bf489dc590a5
Source dataset
uspto-grants-1997_01
Patent number
US05593989

Reaction notes

Loading…