反应详情

温度

60 °C

To a solution of N-(5-chloro-4-methoxy-2-nitrophenyl)-acetamide (2 g, 8.2 mmol) in 5N HCl (20 mL) is added 1,4-dioxane (10 mL), and the mixture is stirred at 60° C. for 1.5 hours. The reaction mixture is concentrated and partitioned between EtOAc/2 N NaOH. The aqueous layers are washed with EtOAc (3×), brine, dried (MgSO4), adsorbed onto silica gel, and chromatographed (70% EtOAc/hexanes) to provide an orange powder.

1. concentrationThe reaction mixture is concentrated
2. custompartitioned between EtOAc/2 N NaOH
3. washThe aqueous layers are washed with EtOAc (3×), brine
4. dry with materialdried (MgSO4)
5. customchromatographed (70% EtOAc/hexanes)
6. customto provide an orange powder