反应详情

A stirred mixture of (2β,3α,5α)-21-chloro-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)pregnane-11,20-dione (500 mg), sodium azide (140 mg), N,N-dimethylformamide (1.25 ml) in methanol (10 ml) and water (0.25 ml) was heated under reflux for 2 h, then cooled and poured into water (50 ml). The resulting precipitate was filtered off and dissolved in dichloromethane. After washing the solution with water and drying over sodium sulfate, the solvent was removed under reduced pressure and the residue (422 mg) was chromatographed on silica gel. The purified product was crystallised from dichloromethane-methanol to give (2β,3α,5α)-21-azido-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)pregnane-11,20-dione (176 mg). δ (CDCl3) 0.62 (s,3H), 1.06 (s,3H), 1.22 (s,3H), 1.24 (s,3H) and 3.85 (s,2H).

1. temperaturewas heated
2. temperatureunder reflux for 2 h
3. temperaturecooled
4. filtrationThe resulting precipitate was filtered off
5. dissolutiondissolved in dichloromethane
6. washAfter washing the solution with water
7. dry with materialdrying over sodium sulfate
8. customthe solvent was removed under reduced pressure
9. customthe residue (422 mg) was chromatographed on silica gel
10. customThe purified product was crystallised from dichloromethane-methanol