Trifluoroacetic acid → 3-(4-(2-chloro-5-methoxypyrimidin-4-yl)-1H-pyrazol-1-yl)-4-(piperidin-4-yl)butanenitrile

HRID 2335253Notes

Reaction equation

HRID 2335253 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([O:31][CH3:32])[c:6](-[c:8]2[cH:9][n:10][n:11]([CH:13]([CH2:14][CH:15]3[CH2:16][CH2:17][N:18]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:19][CH2:20]3)[CH2:28][C:29]#[N:30])[cH:12]2)[n:7]1.[F:33][C:34]([F:35])([F:36])[C:37]([OH:38])=[O:39]>>[Cl:1][c:2]1[n:3][cH:4][c:5]([O:31][CH3:32])[c:6](-[c:8]2[cH:9][n:10][n:11]([CH:13]([CH2:14][CH:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[CH2:28][C:29]#[N:30])[cH:12]2)[n:7]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86637304tert-butyl 4-{2-[4-(2-chloro-5-methoxypyrimidin-4-yl)-1H-pyrazol-1-yl]-3-cyanopropyl}piperidine-1-carboxylate

Product 1

HCID 866373053-(4-(2-chloro-5-methoxypyrimidin-4-yl)-1H-pyrazol-1-yl)-4-(piperidin-4-yl)butanenitrile

Sources & evidence

ORD record
ord-c2913b5f016449c6948786e0854a2e27
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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