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HRID233527

反应详情

EQUATION

反应方程式

HRID 233527 的结构方程式

REACTANTS

反应物

2
结构：CS(=O)(=O)O
HCID6395

Methanesulfonic acid

CH4O3S

结构：CC1(C)CN([C@H]2C[C@@]3(C)[C@@H](CC[C@@H]4[C@@H]3CC[C@]3(C)[C@@H](C#N)CC[C@@H]43)C[C@@H]2O)CCO1
HCID54130454

未命名化合物

PRODUCTS

生成物

1
结构：CC1(C)CN([C@H]2C[C@@]3(C)[C@@H](CC[C@@H]4[C@@H]3CC[C@]3(C)[C@@H](C#N)CC[C@@H]43)C[C@@H]2O)CCO1.CS(=O)(=O)O
HCID86750184

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

2 次

PROCEDURE

实验过程

A solution of methanesulfonic acid (186 mg) in ethanol (2 ml) was added to a suspension of (2β,3α,5α,17β)-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)androstane-17-carbonitrile (800 mg) in ethanol (8 ml) and the mixture was stirred for 5 min. Removal of the solvent under reduced pressure afforded a solid which was precipitated from ethanol-diethyl ether to give (2β,3α,5α,17β)-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)androstane-17-carbonitrile methanesulfonate (1:1) salt (890 mg). [α]D +100.2° (c 0.2).

WORKUP

后处理

  1. customRemoval of the solvent under reduced pressure
  2. customafforded a solid which
  3. customwas precipitated from ethanol-diethyl ether