Triethylamine → 4-chloro-N-[5-chloro-2-(8-fluoro-2,3-dihydro-benzo[1,4]oxazine-4-carbonyl)-pyridin-3-yl]-3-trifluoromethyl-benzenesulfonamide

HRID 2335360Notes

Reaction equation

HRID 2335360 reaction equation
[CH3:37][CH2:38][N:39]([CH2:40][CH3:41])[CH2:42][CH3:43].[Cl:12][c:13]1[cH:14][c:15]([NH:22][S:23](=[O:24])(=[O:25])[c:26]2[cH:27][c:28]([C:33]([F:34])([F:35])[F:36])[c:29]([Cl:32])[cH:30][cH:31]2)[c:16]([C:19](=[O:20])[OH:21])[n:17][cH:18]1.[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:11]1[O:10][CH2:9][CH2:8][NH:7]2>>[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:11]1[O:10][CH2:9][CH2:8][N:7]2[C:19]([c:16]1[c:15]([NH:22][S:23](=[O:24])(=[O:25])[c:26]2[cH:27][c:28]([C:33]([F:34])([F:35])[F:36])[c:29]([Cl:32])[cH:30][cH:31]2)[cH:14][c:13]([Cl:12])[cH:18][n:17]1)=[O:20]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 162444518-Fluoro-3,4-dihydro-2H-1,4-benzoxazineHCID 579420775-Chloro-3-(4-chloro-3-trifluoromethyl benzenesulfonylamino)-pyridine-2-carboxylic acid

Product 1

HCID 579424214-chloro-N-[5-chloro-2-(8-fluoro-2,3-dihydro-benzo[1,4]oxazine-4-carbonyl)-pyridin-3-yl]-3-trifluoromethyl-benzenesulfonamide

Sources & evidence

ORD record
ord-465591ec15f04cdaa7f85da7490e1ba7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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