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温度

0 °C

A solution of bromo(4-nitrophenyl)acetaldehyde and potassium thiocyanate (1.2 equivalents) in methanol is stirred at room temperature for 1 hour. The cyclohexylamine (1,05 equivalents) is added drop-wise and the mixture is heated under reflux until completion of the reaction (5-12 hours). After cooling to 0° C. the precipitate is filtered off and washed with water. The crude material is purified by usual silica gel chromatography to give the desired compound.

1. temperaturethe mixture is heated
2. temperatureunder reflux until completion of the reaction (5-12 hours)
3. filtrationis filtered off
4. washwashed with water
5. customThe crude material is purified by usual silica gel chromatography