Cyclohexylamine → n-Cyclohexyl-5-(4-nitrophenyl)-1,3-thiazol-2-amine

Participants

Reaction Conditions

Reaction Steps

A solution of bromo(4-nitrophenyl)acetaldehyde and potassium thiocyanate (1.2 equivalents) in methanol is stirred at room temperature for 1 hour. The cyclohexylamine (1,05 equivalents) is added drop-wise and the mixture is heated under reflux until completion of the reaction (5-12 hours). After cooling to 0° C. the precipitate is filtered off and washed with water. The crude material is purified by usual silica gel chromatography to give the desired compound.

Provenance & Evidence