Cyclohexylthiourea → 7-[2-(Cyclohexylamino)-1,3-thiazol-5-yl]quinazolin-4(3h)-one

Participants

Reaction Steps

A solution of bromo-(4-oxo-3,4-dihydro-quinazolin-7-yl)acetaldehyde and N-cyclohexylthiourea in dimethylformamide is heated at 70° C. until completion of the reaction (5-12 hours). The mixture is quenched with 10% dimethylamine in ethanol and the solvent is removed under reduced pressured. The crude is purified by chromatography on silica gel to isolate the desired compound.

Provenance & Evidence