反应详情

A solution of bromo-(4-oxo-3,4-dihydro-quinazolin-7-yl)acetaldehyde and N-cyclohexylthiourea in dimethylformamide is heated at 70° C. until completion of the reaction (5-12 hours). The mixture is quenched with 10% dimethylamine in ethanol and the solvent is removed under reduced pressured. The crude is purified by chromatography on silica gel to isolate the desired compound.

1. customThe mixture is quenched with 10% dimethylamine in ethanol
2. customthe solvent is removed
3. customThe crude is purified by chromatography on silica gel