Trimethyl borate → HCID 19707206, compound

HRID 233597Notes

Reaction equation

HRID 233597 reaction equation
[F:1][C:2]1[CH:3]=[C:4](Br)[CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:7]=1.C([Li])CCC.[B:22](OC)([O:25]C)[O:23]C>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([B:22]([OH:25])[OH:23])[CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 8470Trimethyl borateHCID 197072103-Fluoro-5-(4-fluorophenoxy)phenyl bromideHCID 178418339Butyllithium

Product 1

HCID 19707206HCID 19707206, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound is prepared in a manner analogous to that of Step B of Example 6, using 9.1 grams (0.032 mole) of 3-fluoro-5-(4-fluorophenoxy)phenyl bromide, 14 mL (0.035 mole) of n-butyllithium (2.5M in hexanes), and 10.4 mL (0.095 mole) of trimethyl borate in 100 mL of tetrahydrofuran, yielding 3-fluoro-5-(4-fluorophenoxy)phenylboronic acid.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step B of Example 6

Sources & evidence

ORD record
ord-8800c26e98b84206a7b1f30d86c64da1
Source dataset
uspto-grants-1997_01
Patent number
US05593998

Reaction notes

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