反应详情

The compound of Example 37 (640 mg, 2.75 mmol) was dissolved in dry THF (30 ml) and borane-tetrahydrofuran complex (5 ml, 1M solution in THF) was added. The mixture was stirred under nitrogen under reflux for 1 h, then cooled and evaporated. The residue was taken up in MeOH/acetic acid (6/1, v/v, 70 ml) and heated under reflux for 3 h, then evaporated and chromatographed (eluant 10% EtOAc in hexanes) to provide a colourless oil (540 mg, 90%).

1. temperatureunder reflux for 1 h
2. temperaturecooled
3. customevaporated
4. temperatureheated
5. temperatureunder reflux for 3 h
6. customevaporated
7. customchromatographed (eluant 10% EtOAc in hexanes)