Methanol → 6-chloro-4'-[5-chloro-2-(1-ethyl-1-hydroxycarbonyl-propoxy)-phenyl]-2'-(5-fluoro-2-methyl-phenyl) spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione
Reaction equation
[CH3:47][OH:48].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:35]2[c:36]([CH3:42])[cH:37][cH:38][c:39]([F:41])[cH:40]2)[NH:13][C:14](=[O:34])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][C:25]([CH2:26][CH3:27])([C:28](=[O:29])[O:30][CH3:31])[CH2:32][CH3:33])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1.[Li+:44].[OH-:43].[OH2:45].[OH2:46]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:35]2[c:36]([CH3:42])[cH:37][cH:38][c:39]([F:41])[cH:40]2)[NH:13][C:14](=[O:34])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][C:25]([CH2:26][CH3:27])([C:28](=[O:29])[OH:30])[CH2:32][CH3:33])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-c44904d580af4047a338ec6a5017626c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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