Tetrahydrofuran → (3-(tert-butyldimethylsilyloxy)-5-ethyl-2-fluorophenyl) (4-phenyl-1-trityl-1H-imidazol-2-yl)methanol

HRID 2336703Notes

Reaction equation

HRID 2336703 reaction equation
[C:36]([CH3:37])([CH3:38])([CH3:39])[Si:40]([O:41][c:42]1[c:43]([F:52])[c:44]([CH:45]=[O:46])[cH:47][c:48]([CH2:50][CH3:51])[cH:49]1)([CH3:53])[CH3:54].[CH2:55]1[O:56][CH2:57][CH2:58][CH2:59]1.[CH3:31][CH2:32][CH2:33][CH2:34][Li:35].[c:1]1(-[c:7]2[n:8][cH:9][n:10]([C:12]([c:13]3[cH:14][cH:15][cH:16][cH:17][cH:18]3)([c:19]3[cH:20][cH:21][cH:22][cH:23][cH:24]3)[c:25]3[cH:26][cH:27][cH:28][cH:29][cH:30]3)[cH:11]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1(-[c:7]2[n:8][c:9]([CH:45]([c:44]3[c:43]([F:52])[c:42]([O:41][Si:40]([C:36]([CH3:37])([CH3:38])[CH3:39])([CH3:53])[CH3:54])[cH:49][c:48]([CH2:50][CH3:51])[cH:47]3)[OH:46])[n:10]([C:12]([c:13]3[cH:14][cH:15][cH:16][cH:17][cH:18]3)([c:19]3[cH:20][cH:21][cH:22][cH:23][cH:24]3)[c:25]3[cH:26][cH:27][cH:28][cH:29][cH:30]3)[cH:11]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 102217694-phenyl-1-(triphenylmethyl)-1H-imidazoleHCID 598380723-{[tert-Butyl(dimethyl)silyl]oxy}-5-ethyl-2-fluorobenzaldehydeHCID 178418339Butyllithium

Product 1

HCID 69125238(3-(tert-butyldimethylsilyloxy)-5-ethyl-2-fluorophenyl) (4-phenyl-1-trityl-1H-imidazol-2-yl)methanol

Sources & evidence

ORD record
ord-015898d8bae6438c8762f9eabb54beb2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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