Hydrochloric Acid → Hydrochloric Acid

HRID 2336893Notes

Reaction equation

HRID 2336893 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]2[C:11]([c:18]3[c:19]([F:24])[cH:20][cH:21][cH:22][cH:23]3)([c:25]3[c:26]([F:31])[cH:27][cH:28][cH:29][cH:30]3)[CH2:12][CH2:13][C:14](=[O:17])[CH:15]2[CH2:16]1.[CH3:33][OH:34].[ClH:32].[Pd:35]>>[ClH:32].[NH:8]1[CH2:9][CH:10]2[C:11]([c:18]3[c:19]([F:24])[cH:20][cH:21][cH:22][cH:23]3)([c:25]3[c:26]([F:31])[cH:27][cH:28][cH:29][cH:30]3)[CH2:12][CH2:13][C:14](=[O:17])[CH:15]2[CH2:16]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 23938PalladiumHCID 67915773(3aRS,7aRS)-2-benzyl-7,7-bis(2-fluorophenyl)perhydro-4-isoindolone

Product 2

HCID 313Hydrochloric AcidHCID 98187837,7-bis(2-fluorophenyl)-2,3,3a,5,6,7a-hexahydro-1H-isoindol-4-one

Sources & evidence

ORD record
ord-eca074c25e62451b9d1ede2f700a1e47
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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