HCID 20756582, compound → HCID 66912321, compound

HRID 23370Notes

Reaction equation

HRID 23370 reaction equation
CC(C)(OC(N[C@H]([C:19]1[N:20](CC(=O)C2C=CC=CC=2)[CH:21]=[C:22](C2C=CC=CC=2)[N:23]=1)CC1C2C(=CC=CC=2)NC=1)=O)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH:20]1[C:21]2[N:20]=[CH:21][CH:22]=[N:23][C:22]=2[NH:23][CH2:19]1

Participants

4

Reactant 1

HCID 20756582HCID 20756582, compound

Product 1

HCID 66912321HCID 66912321, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
20 °C

Procedure

A solution of 2-[1(S)-{(1,1-dimethylethoxy)carbonylamino}-2-(3-indolyl)ethyl]-1-(benzoylmethyl)-4-phenyl-1H-imidazole (prepared as described previously) (100 mg) in a mixture of 10% TFA in DCM (1.3 mL) was stirred for about 3 hours at about 20° C. and concentrated under reduced pressure to yield the expected dihydro-imidazo-pyrazine (yield=95%). LC/MS: calculated MW: 402.19, m/z=403.2 (M+H).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3b18b66de54c42ee9ce2a88be23e2473
Source dataset
uspto-grants-2005_02
Patent number
US06852725B1

Reaction notes

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