(3-Methoxypyridin-2-yl)acetonitrile → HCID 69946004, compound

2-[(3-methoxy)pyridyl]acetonitrile (2.0 g, 13 mmol) in 25 ml ethanol was reduced at room temperature under 60 p.s.i. for 24 h using platinum oxide (0.5 g) and 5N HCl (0.2 ml) as catalyst. The organics were concentrated and then taken up in ethyl acetate and water. 1N NaOH was added to pH 12 and the amine was extracted out (2×300 ml ethyl acetate). The organics were then washed with brine and saturated sodium bicarbonate and then dried over sodium sulfate. The solution is filtered and concentrated giving 1.5 g of oily material. This is used without further purification.

1. customwas reduced at room temperature under 60 p.s.i
2. concentrationThe organics were concentrated
3. addition1N NaOH was added to pH 12
4. extractionthe amine was extracted out (2×300 ml ethyl acetate)
5. washThe organics were then washed with brine and saturated sodium bicarbonate
6. dry with materialdried over sodium sulfate
7. filtrationThe solution is filtered
8. concentrationconcentrated

ORD record

ord-7503c19868dc49e1b0fbec33a264ec17

Source dataset

uspto-grants-1997_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05593993