Sodium ion → alpha-(Chloromethyl)-4'-[(difluoromethyl)thio][1,1'-biphenyl]-4-methanol

HRID 2337589Notes

Reaction equation

[BH4-:21].[CH2:23]1[O:24][CH2:25][CH2:26][CH2:27]1.[Cl:1][CH2:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8](-[c:11]2[cH:12][cH:13][c:14]([S:17][CH:18]([F:19])[F:20])[cH:15][cH:16]2)[cH:9][cH:10]1.[Na+:22]>>[Cl:1][CH2:2][CH:3]([OH:4])[c:5]1[cH:6][cH:7][c:8](-[c:11]2[cH:12][cH:13][c:14]([S:17][CH:18]([F:19])[F:20])[cH:15][cH:16]2)[cH:9][cH:10]1

Participants

Reactant 4

HCID 923Sodium ion

HCID 8028Tetrahydrofuran

HCID 28123Borohydride

HCID 187864052-Chloro-1-[4'-[(difluoromethyl)thio][1,1'-biphenyl]-4-yl]ethanone

Product 1

HCID 18786418alpha-(Chloromethyl)-4'-[(difluoromethyl)thio][1,1'-biphenyl]-4-methanol

Sources & evidence

ORD record: ord-863cd2c846674f0aa4c0021990295b3e
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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