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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2337821Generated: October 30, 2026

1,4-Dioxane → 3-[4-chloro-6-fluoro-3-hydroxy-2-(2-naphthoylamino)phenyl]-1-methyl-6-trifluoromethyl-2,4(1H, 3H)-pyrimidinedione

https://huagongshe.com/reaction/2337821

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-DioxaneHCID 31275—
Reactant2-Naphthoyl chlorideHCID 75246—
Reactant1-methyl-6-trifluoromethyl-3-(6-amino4-chloro-2-fluoro-5-hydroxyphenyl)-2,4(1H,3H)-pyrimidinedioneHCID 12056912—
Product3-[4-chloro-6-fluoro-3-hydroxy-2-(2-naphthoylamino)phenyl]-1-methyl-6-trifluoromethyl-2,4(1H, 3H)-pyrimidinedioneHCID 57152878—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (10/10)
ORD IDord-a2e6c6d0a2054a83bce60b1ceca3800b
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (10/10)