Propylamine → HCID 19043203, compound

HRID 233807Notes

Reaction equation

HRID 233807 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH:10]([CH3:12])[C:9](=O)[CH2:8][CH2:7]2.S([O-])([O-])(=O)=O.[Mg+2].[CH2:20]([NH2:23])[CH2:21][CH3:22]>ClCCl>[CH3:12][CH:10]1[C:11]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[Br:1])[CH2:7][CH2:8][C:9]1=[N:23][CH2:20][CH2:21][CH3:22]

Participants

5

Reactant 3

HCID 7852PropylamineHCID 24083Sulfuric acid magnesium salt (1:1)HCID 19043184HCID 19043184, compound

Product 1

HCID 19043203HCID 19043203, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 8-bromo-1-methyl-2-tetralone (4.05 gm, 16.9 mMol) in dichloromethane (60 mL) were added magnesium sulfate (3.0 gm, 25 mMol) and n-propylamine (2.0 mL, 24.4 mMol). The mixture was stirred at room temperature for twenty hours. The reaction mixture was filtered through a bed of celite and the filtrate concentrated in vacuo to give 1-methyl-2-n-propylimino-8-bromo-1,2,3,4-tetrahydronaphthalene as a dark residue.

Workup

  1. filtrationThe reaction mixture was filtered through a bed of celite
  2. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-6dcf3f59fd9b407b90dfa19d088ace0a
Source dataset
uspto-grants-1997_01
Patent number
US05594025

Reaction notes

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