2-(Bromomethyl)tetrahydro-2H-pyran → 1'-(4-fluoro-3-methoxybenzyl)-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

HRID 2338187Notes

Reaction equation

HRID 2338187 reaction equation
[Br:12][CH2:13][CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][O:19]1.[Cl:1][CH2:2][c:3]1[cH:4][c:5]([O:10][CH3:11])[c:6]([F:9])[cH:7][cH:8]1.[NH:20]1[C:21](=[O:41])[C:22]2([CH2:23][O:24][c:25]3[cH:26][c:27]4[c:28]([cH:33][c:34]32)[O:29][CH2:30][CH2:31][O:32]4)[c:35]2[cH:36][cH:37][cH:38][cH:39][c:40]21>>[CH2:2]([c:3]1[cH:4][c:5]([O:10][CH3:11])[c:6]([F:9])[cH:7][cH:8]1)[N:20]1[C:21](=[O:41])[C:22]2([CH2:23][O:24][c:25]3[cH:26][c:27]4[c:28]([cH:33][c:34]32)[O:29][CH2:30][CH2:31][O:32]4)[c:35]2[cH:36][cH:37][cH:38][cH:39][c:40]21

Participants

4

Reactant 3

HCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 179642394-(Chloromethyl)-1-fluoro-2-methoxybenzeneHCID 58224164Spiro[furo[2,3-g]-1,4-benzodioxin-8(7H),3'-[3H]indol]-2'(1'H)-one, 2,3-dihydro

Product 1

HCID 461947101'-(4-fluoro-3-methoxybenzyl)-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-762edd173c2b459cabf569c48d75dd66
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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