1-(4,5-dihydro-1H-imidazol-2-ylmethyl)-3-methanesulfonyl-5-nitro-1H-indole → 1-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-3-methanesulfonyl-1H-indol-5-ylamine

HRID 23382Notes

Reaction equation

HRID 23382 reaction equation
[NH:1]1[CH2:5][CH2:4][N:3]=[C:2]1[CH2:6][N:7]1[C:15]2[C:10](=[CH:11][C:12]([N+:16]([O-])=O)=[CH:13][CH:14]=2)[C:9]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:8]1>C(#N)C>[NH:3]1[CH2:4][CH2:5][N:1]=[C:2]1[CH2:6][N:7]1[C:15]2[C:10](=[CH:11][C:12]([NH2:16])=[CH:13][CH:14]=2)[C:9]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:8]1

Participants

3

Reactant 1

HCID 225740651-(4,5-dihydro-1H-imidazol-2-ylmethyl)-3-methanesulfonyl-5-nitro-1H-indole

Product 1

HCID 225740671-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-3-methanesulfonyl-1H-indol-5-ylamine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-3-methanesulfonyl-1H-indol-5-ylamine, (mp 215-217° C.) was prepared by reduction of the nitro group of compound 1-(4,5-dihydro-1H-imidazol-2-ylmethyl)-3-methanesulfonyl-5-nitro-1H-indole, with TiCl3 in aqueous acetonitrile.

Sources & evidence

ORD record
ord-1c0f7b4c850c406c8254f9497e6ce443
Source dataset
uspto-grants-2005_02
Patent number
US06852726B2

Reaction notes

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