Methanesulfonyl chloride → 1-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-3-methanesulfonyl-7-methyl-1H-indole

HRID 23383Notes

Reaction equation

HRID 23383 reaction equation
[CH3:1]S(N)(=O)=O.[NH:6]1[CH2:10][CH2:9][N:8]=[C:7]1[CH2:11][N:12]1[C:20]2[C:15](=[CH:16][C:17](N)=[CH:18][CH:19]=2)[C:14]([S:22]([CH3:25])(=[O:24])=[O:23])=[CH:13]1.CS(Cl)(=O)=O>N1C=CC=CC=1>[NH:6]1[CH2:10][CH2:9][N:8]=[C:7]1[CH2:11][N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:1])[C:14]([S:22]([CH3:25])(=[O:24])=[O:23])=[CH:13]1

Participants

5

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 72879MethanesulfonamideHCID 225740671-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-3-methanesulfonyl-1H-indol-5-ylamine

Product 1

HCID 225740451-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-3-methanesulfonyl-7-methyl-1H-indole

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-1-(4,5-dihydro-1H-imidazol-2-ylmethyl)-3-methanesulfonyl-1H-indol-5-yl]-methanesulfonamide, mp 232-233° C., was prepared from 1-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-3-methanesulfonyl-1H-indol-5-ylamine by treatment with methane sulfonylchloride and pyridine.

Sources & evidence

ORD record
ord-9bba4ad2e62d451cbd558b074d46a657
Source dataset
uspto-grants-2005_02
Patent number
US06852726B2

Reaction notes

Loading…