p-Toluenesulfonic acid → Methyl 4-(4-fluoro-2-(tetrahydro-2H-pyran-4-yloxy)phenylamino)thieno[2,3-d]pyrimidine-6-carboxylate

HRID 2339086Notes

Reaction equation

HRID 2339086 reaction equation
[CH2:41]1[O:42][CH2:43][CH2:44][O:45][CH2:46]1.[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[s:8][c:9]([C:11](=[O:12])[O:13][CH3:14])[cH:10]2.[F:15][c:16]1[cH:17][c:18]([O:23][CH:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[c:19]([NH2:20])[cH:21][cH:22]1.[c:30]1([CH3:31])[cH:32][cH:33][c:34]([S:35]([OH:36])(=[O:37])=[O:38])[cH:39][cH:40]1>>[c:2]1([NH:20][c:19]2[c:18]([O:23][CH:24]3[CH2:25][CH2:26][O:27][CH2:28][CH2:29]3)[cH:17][c:16]([F:15])[cH:22][cH:21]2)[c:3]2[c:4]([n:5][cH:6][n:7]1)[s:8][c:9]([C:11](=[O:12])[O:13][CH3:14])[cH:10]2

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 312751,4-DioxaneHCID 17965841Methyl 4-chlorothieno[2,3-d]pyrimidine-6-carboxylateHCID 584130794-Fluoro-2-(oxan-4-yloxy)aniline

Product 1

HCID 46182082Methyl 4-(4-fluoro-2-(tetrahydro-2H-pyran-4-yloxy)phenylamino)thieno[2,3-d]pyrimidine-6-carboxylate

Sources & evidence

ORD record
ord-da9f802c40f04a7bb962d4529b1080d9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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