Dimethylformamide → 5-[2,2-Dimethyl-6-(1-methyl-1H-pyrazol-3-ylcarbamoyl)-2,3-dihydro-benzofuran-4-yloxy]-pyridine-2-carboxylic acid methyl ester

HRID 2339114Notes

Reaction equation

HRID 2339114 reaction equation
[C:33](=[O:34])([O-:35])[O-:36].[CH3:12][n:13]1[n:14][c:15]([NH:18][C:19](=[O:20])[c:21]2[cH:22][c:23]3[c:24]([c:30]([OH:32])[cH:31]2)[CH2:25][C:26]([CH3:28])([CH3:29])[O:27]3)[cH:16][cH:17]1.[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][cH:7][c:8]([F:11])[cH:9][cH:10]1.[Cs+:37].[Cs+:38].[O:39]=[CH:40][N:41]([CH3:42])[CH3:43]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][cH:7][c:8]([O:32][c:30]2[c:24]3[c:23]([cH:22][c:21]([C:19]([NH:18][c:15]4[n:14][n:13]([CH3:12])[cH:17][cH:16]4)=[O:20])[cH:31]2)[O:27][C:26]([CH3:28])([CH3:29])[CH2:25]3)[cH:9][cH:10]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 23053520Methyl 5-fluoropyridine-2-carboxylateHCID 595600842,3-Dihydro-4-hydroxy-2,2-dimethyl-N-(1-methyl-1H-pyrazol-3-yl)-6-benzofurancarboxamide

Product 1

HCID 595601495-[2,2-Dimethyl-6-(1-methyl-1H-pyrazol-3-ylcarbamoyl)-2,3-dihydro-benzofuran-4-yloxy]-pyridine-2-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-b1d0f4dec24a40cbaf88d132f824cbe5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…